's Avatar

seplite April 26

Polypeptide is a kind of compound which is made up of many amino acids connected by peptide bond. It is usually composed of 2-100 amino acid molecules. It has biological activity and can participate in and regulate the functional activities of organs, tissues and cells in the body. With the development of science and technology as well as the deepening of human understanding of polypeptide research, the high-specific biological activity of polypeptide molecules with different structures has been gradually recognized and applied. For example, peptide drugs are the preparation of peptides with specific amino acid sequence by artificial way, which can be used for the prevention and treatment of some diseases. How to get the amino acid sequence peptide we want has naturally become the core topic in the field of peptide research and production.
In 1963, a pioneering work of Merrifield, an American biochemist, overturned people's cognition of peptide synthesis. The technology of solid-phase peptide synthesis (SPPs) came out quietly, which had a profound impact on peptide synthesis. Solid phase peptide synthesis technology has become the mainstream technology in the field of peptide synthesis due to its advantages of good yield, high purity, stable quality and environmental friendliness. It has been widely used in the preparation of 3-50 amino acid sequence peptides.
With the development of solid-phase peptide synthesis technology, equipment, synthesis carrier and technology, there are more and more kinds of synthetic peptides, which benefit people's livelihood. The solid-phase synthesis of polypeptide mainly includes synthesis, peptide cutting, purification, concentration, freeze-drying, packaging and other technological processes. The selection of raw materials, reagents and technological control in each step will affect the yield and quality of polypeptide.
As the key raw material of peptide solid-phase synthesis, solid-phase carrier's swelling degree, substitution degree, particle size, residue, reaction site distribution and other key indicators will affect the yield and purity of peptide synthesis. The swelling degree, substitution degree and particle size of the carrier can be well controlled by adjusting the technological parameters of the carrier synthesis. However, at present, the distribution of carrier reaction sites is non-uniform. With the growth of peptide chain in the process of peptide synthesis, the growth space of peptides in the carrier is gradually reduced. The non-uniform distribution of reaction sites will bring local space hindrance to the growth of peptide chain, reduce the probability of contact reaction between amino acids and pre peptide chain, and increase the probability of missing peptide and inserted peptide of impurities, affecting yield. This is especially obvious on the synthesis of long-chain peptides.
Sunresin, as the world's leading supplier of solid-phase synthesis carriers for peptides, has developed the Seplife® UNI series of solid-phase synthesis carriers with uniform reaction site distribution based on the traditional solid-phase carrier synthesis technology, aiming at the problem of space hindrance in the synthesis process. Under the premise of not changing the structure of the original carrier, the series of carriers can realize the uniform distribution of reaction sites in the carrier through special process control, improve the carrier space resistance in the process of peptide synthesis to the maximum extent, make the solid-phase synthesis of special difficult synthetic peptides and long-chain peptides easier, and the yield of medium and short-chain peptide synthesis unit carrier is higher.
Seplife® UNI series solid phase carrier advantages
(1)It can effectively reduce the hindrance effect in the synthesis process.
(2)The distribution of functional sites is uniform, which can improve the contact rate of amino acids and pro peptides in long peptide synthesis.
(3)The reaction efficiency is high, the reaction time is shortened, and the racemic risk caused by prolonged reaction is reduced.
As the first and the only A-share listed company in Chinese Ion Exchange and Adsorption Resin Industry, Sunresin manufactures about 50,000 cubic meters of ion exchange resin China and adsorption resins annually, and supplies customers with tens of adsorption and separation equipment.

seplite.com/seplife-un…

#ion #exchange #resin #China

  • Polypeptide is a kind of compound which is made up of many a... via seplite

Avatar



's Avatar

seplite April 26

Green chemistry, also known as environmentally benign chemistry, environmentally friendly chemistry, or clean chemistry, is a green chemical process that aims to reduce or eliminate the use or generation of hazardous substances and pollutants, and advocates the use of chemical technologies and methods to reduce or stop the use of raw materials, catalysts, solvents, etc., as well as the generation of products and by-products that are harmful to human health, social security and ecological environment. How to better realize the "atomic economic reaction (that is, every atom of the raw material molecule can make the best use of everything)" and "circular economy" in the process of chemical reaction has become an important category and development direction of green chemistry research. Today, with the advocacy of ecological friendly and sustainable development of industry, many countries around the world have taken "green chemistry" as an important direction for the development of chemical industry in the new century.
In the field of chemical catalysis, sulfuric acid (H2SO4) is the catalyst for many organic synthesis reactions in acid system. Taking the common etherification reaction as an example, the traditional processes all use concentrated sulfuric acid as catalyst, which has serious equipment corrosion, many side reactions, difficult product separation, catalyst environmental pollution and other problems, bringing double pressure of cost and environmental protection to the production enterprises, which has become a prominent problem faced by the chemical production enterprises and needs to be solved urgently.
Sunresin, based on its deep understanding of the structure and properties of resin, combining the principle and characteristics of acid catalytic reaction, has developed a series of resin acid catalysts represented by Seplite ® CT-101, which can be used in different types of chemical acid catalytic reactions. Taking etherification as an example, because the introduction of resin acid catalyst replaces the use of traditional liquid inorganic acid, the catalytic activity, reaction conversion rate, product purity and other aspects are better; at the same time, the environmental protection problems caused by the use of hazardous chemical concentrated sulfuric acid are avoided. The change of catalyst not only reduces the cost of production, but also fundamentally relieves the pressure of environmental protection.
Advantages of Seplite® CT-101 resin acid catalyst
(1)The unique design of multi-channel, high specific surface area structure features higher catalytic activity.
(2)It has good mechanical strength and physical and chemical stability, making it not easy to break, and has good durability.
(3)It is easy to separate from raw materials and products.
(4)It can be recycled periodically.
As the first and the only A-share listed company in Chinese Ion Exchange and Adsorption Resin Industry, Sunresin manufactures about 50,000 cubic meters of ion exchange resin China and adsorption resins annually, and supplies customers with tens of adsorption and separation equipment.

seplite.com/seplite-ct…

#resin #China

  • Green chemistry, also known as environmentally benign chemis... via seplite

Avatar



's Avatar

seplite April 26

Lactic acid is a kind of multi-purpose organic acid and it is also one of the three recognized organic acids in the world. It is made of starch (such as corn, rice, dried potato, etc.) by biological fermentation. The global lactate consumption market is about 500000 tons / year, which is widely used in food, medicine, chemical industry and other industries.
In the fermentation process of lactic acid, calcium salt is often used to neutralize the lactic acid produced in the fermentation process and keep the pH of the system within a suitable range to ensure the normal fermentation of bacteria. The resulting crude calcium lactate fermentation liquid needs to be treated with multi-stage anion and cation exchange resin to produce the required lactic acid products. In the process of multi-stage ion exchange resin China purification, anion exchange resin refining is the most important part. The performance of anion exchange resin will directly affect the purification effect, efficiency and cost. Therefore, the selection of anion exchange resin in this process has naturally become the focus of the relevant manufacturers in the industry.
Sunresin Seplite® LX-6703 food grade macroporous acrylic acid weak base anion exchange resin, due to its good particle size uniformity, higher exchange capacity and exchange speed, as well as superior mechanical strength and impermeability, has shown excellent effect in the purification process of lactic acid. In the application evaluation of industrial customers, its extraordinary performance has been fully verified and affirmed. As a promising product in the purification process of lactic acid, Seplite® LX-6703 is bound to fulfill its mission and create greater value for customers.
The advantages of Sunresin Seplite® LX-6703 are summarized as follows:
(1)The resin exchange capacity is larger, which can significantly improve the processing capacity and reduce the production cost.
(2)Resin exchange speed is faster, which can significantly improve the treatment efficiency.
(3)Resin treatment has higher precision.
(4)The special resin white beads process enables the resin to have better resistance to high concentration organic acid osmotic pressure. After long-term repeated regeneration, the resin can still maintain good mechanical strength.
(5)The resin channels are more well-distributed, and the resin is easy to regenerate, and has good anti-pollution performance.
(6)The resin particle size is more uniform, which can bring better hydraulic properties in use, and the system pressure drop is smaller.

seplite.com/weak-base-…

#ion #exchange #resin #China

  • Lactic acid is a kind of multi-purpose organic acid and it i... via seplite

Avatar